The Skinny on Weight Loss Drug Microdosing

I don't want to do this forever

Photo by Diana Polekhina on Unsplash

On my way home from the Catskills last night I read this terrifying story from Jenny Mollen about the side effects and potential medical complications of microdosing Tirzepatide, one of the GLP1s.

Jenny wrote: while I loved the fact that I could finally live like a normal person, indulging in food-related activities I’d spent most of my adulthood trying to avoid, I had growing concerns about how the drug was affecting me mentally.

When I started Tirzepatide, the first thing I noticed was that I was crying more frequently. I couldn’t control the tears that would pour out of me when talking about subjects ranging from kids to open-faced tuna melts. I also noticed this underlying anxiety that would, without warning, after no more than one cup of espresso, take over my body and have me pacing in the kitchen like I’d just snorted an eightball of cocaine. I was more easily offended and quicker to react. I also began to sense that the joy and gratitude I once experienced, those moments of peak happiness, weren’t quite as intense as they used to be.

This freaked me out because I have to say I am quicker to anger than ever and more irritated than I used to be. But I also don’t know if this is a function of the weight loss medicine or the fact that I am a mom of three young kids who just started summer break and I’m about to release a book into a world on fire. It’s like during the peak of the pandemic when I couldn’t tell the difference between a cold, COVID or a hangover.

I just began my media tour today. I have about one on camera interview a day for the next month! Here I am on Milwaukee Morning Blend.

So yeah, I probably care more about how I look than ever and I am a little more vain than usual.

I’ve been microdosing the meds for about a month now (.4 dose of the semaglutide mis) and I want to talk more about what has been happening. PLUS I did a no holds barred convo with my friend Kara Baskin about all her GLP-1 experiences that includes constipation and puking.

I’ll be ending the offer of a free subscription for this newsletter for orders of Everyone is Lying to You on pub week so get those orders in. If every single subscriber to this newsletter gets it now we may defeat the patriarchy and JD Vance will cry and then his eyeliner will run.

Here is the Amazon link. I know it is often the easiest one. This is a list of more purchasing options, but it is also available at a lot of indie bookstores and you can get signed copies mailed to you here and here. Tour stops are here!